University of Minnesota – A Clinical Research Trial Hub
The University Of Minnesota Department Of Emergency Medicine is one of twenty-five research hubs funded by the NIH for neurological emergency studies. It was initially funded in May 2007 for five years and received a five-year renewal grant in September 2012. Dr. Michelle Biros is the Hub Principal Investigator for the NETT, having obtained the initial grant and the renewal award. The NETT is charged with developing a robust research network by engaging local hospitals as “spokes” in their Hub. In ten years we grew from two spokes to eleven spokes actively enrolling subjects in one or more NIH-sponsored studies. In 2017, the NETT research network received a one year no cost extension to complete the current NETT trials: POINT, SHINE and ESETT.
Michelle Biros, MD, MS, Professor of Emergency Medicine and Interim Department Head at University of Minnesota, was an emergency medicine physician at Hennepin County Medical Center for almost 25 years, as well as serving as Interim Department Chief. She has served on the NETT Operations Committee and chairs the Human Subjects Protection Committee for the NETT. Dr. Biros is a well regarded expert in human subject consent policy and exception from informed consent (EFIC) policy. Dr. Biros serves as the University of Minnesota’s IRB expert for research involving vulnerable subjects. Dr. Biros also serves as the PI for the University of Minnesota Hub for the SIREN Clinical Trials Network.
Dr. James Miner (HCMC) is the SIREN Co-PI, in collaboration with domain experts across the SIREN Hub.
Mustapha Ezzeddine, MD, Associate Professor of Neurology, also serves as the Co-PI for the Hub. He is responsible for stroke and neurocritical care fellowship programs and Department of Neurology research in stroke clinical trials. Dr. Ezzeddine is board certified in neurology, stroke and neurocritical care.
Our hub enjoys collaborative relationships with the University of Michigan (which serves as the Clinical Coordinating Center), Medical University of South Carolina (which provides data coordination services for trials) and the respective study sponsors and PIs, and the other hubs participating in the NETT, StrokeNet, and SIREN. Research studies that fall within our expertise are directed toward the trial networks (by the NIH and other government agencies) for hubs to rapidly implement in their hospital sites (spokes). In addition, we provide study coordination services for non-NETT studies on a contract basis.
This network will pursue studies for a broad range of acute and critical care medical situations such as traumatic brain injury and cardiac arrest. In addition to multicenter clinical network affiliations, the Department of Emergency Medicine research team also actively works with local investigators at the University of Minnesota. Utilizing an Internal Service Organization (ISO) agreement, the department is able to provide clinical research services to a multitude of local departments and investigators.
Neurological Emergencies Treatment Trials (NETT) Network
The Department of Emergency Medicine has received a National Institutes of Health (NIH) grant for a second five-year cycle of the project called Neurological Emergencies Treatment Trials (NETT) Network. The grant is to sustain and grow a network to improve the emergency care of patients with neurological emergencies by executing clinical trials. NETT will transition to SIREN in late 2017.
StrokeNet Clinical Trial Research Network
The StrokeNet national research network is coordinated nationally by the University of Cincinnati (NCC) with funding from NIH/NINDS. The network is comprised of 25 academic RCC’s with more than 200 satellites or stroke centers that enroll patients into stroke research studies in cities across the United States.
In 2014, the University of Minnesota Department of Neurology was awarded a National Institute of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) 5-year grant to serve as a Regional Coordinating Center for stroke research. Our goal is to foster participation in clinical trials at comprehensive and primary stroke centers in our region.
Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Network
The Department of Emergency Medicine has received a National Institute of Health (NIH) grant for the successor of NETT, the SIREN clinical research network. This grant is to sustain and grow a network to improve the emergency care of patients within the emergency department or within emergency medical services (prehospital) by executing large multicenter clinical trials.
Learn more about the SIREN Network.
Research Ethics at the University of Minnesota
We are committed to protecting research participants, upholding ethical standards, and improving our practice at every step of our work.