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Completed NETT Trials

ALIAS

Ginsberg MD, Palesch YY, Hill MD, Martin RH, Moy CS, Barsan WG, Waldman BD, Tamariz D, Ryckborst KJ; ALIAS and Neurological Emergencies Treatment Trials (NETT) Investigators. High-dose albumin treatment for acute ischaemic stroke (ALIAS) Part 2: a randomised, double-blind, phase 3, placebo-controlled trial. Lancet Neurol. 2013 Nov;12(11):1049-58. doi: 10.1016/S1474-4422(13)70223-0. Epub 2013 Sep 27. PDF icon Read article.

PEER

Dickert NW, Mah VA, Baren JM, Biros MH, Govindarajan P, Pancioli A, Silbergleit R, Wright DW, Pentz RD. Enrollment in Research Under Exception from Informed Consent: The Patients' Experiences in Emergency Research (PEER) Study. Resuscitation. October 2013; 84 (10):1416-21. doi: 10.1016/j.resuscitation.2013.04.006. Epub 2013 Apr 16. PDF icon Read article.

Dickert NW, Mah VA, Biros MH, Harney DM, Silbergleit R, Sugarman J, Veledar E, Weinfurt KP, Wright DW, Pentz RD. Consulting Communities When Patients Cannot Consent: A Multicenter Study of Community Consultation for Research in Emergency Settings. Critical Care Medicine. 2013 Oct 18. doi: 10.1097/CCM.0b013e3182a27759. PDF icon Read article.

ProTECT

David W. Wright, M.D., Sharon D. Yeatts, Ph.D., Robert Silbergleit, M.D., Yuko Y. Palesch, Ph.D., Vicki S. Hertzberg, Ph.D., Michael Frankel, M.D., Felicia C. Goldstein, Ph.D., Angela F. Caveney, Ph.D., Harriet Howlett-Smith, R.N., Erin M. Bengelink, M.A., Geoffrey T. Manley, M.D., Ph.D., Lisa H. Merck, M.D., M.P.H., L. Scott Janis, Ph.D., and William G. Barsan, M.D. for the NETT Investigators. Very Early Administration of Progesterone for Acute Traumatic Brain Injury. New England Journal of Medicine. 2014. doi: 10.1056NEJMoa1404304. PDF icon Read article.

Biros MH, Dickert NW, Wright DW, Scicluna VM, Harney D, Silbergleit R, Denninghoff K, Pentz RD. Balancing Ethical Goals in Challenging Individual Participant Scenarios Occurring in a Trial Conducted with Exception from Informed Consent. Acad Emerg Med. 2015 Feb 25. doi: 10.1111/acem.12602. [Epub ahead of print] Learn more.

RAMPART

Silbergleit R, Durkalski V, Lowenstein D. et al for the NETT Investigators, Biros, MH. Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus. New England Journal of Medicine, Feb 16, 2012; 366 (7): 591-600. PDF icon Read article.

McMullan JT, Pinnawin A, Jones E, Denninghoff K, Siewart N, Spaite DW, Zaleski E, Silbergleit R; for the Neurological Emergencies Treatment Trials Investigators, Biros, MH. The 60-day temperature-dependent degradation of midazolam and Lorazepam in the prehospital environment. Prehospital Emergency Care. 2013 Jan-Mar;17 (1): 1-7. doi: 10.3109/10903127.2012.722177. Epub 2012 Nov 13. PDF icon Read article.

Silbergleit R, Biros MH, Harney D, Dickert N, Baren J on behalf of the NETT Investigators. Implementation of the Exception from Informed Consent Regulations in a Large Multicenter Emergency Clinical Trials Network: The RAMPART Experience. Academic Emergency Medicine. April 2012; 19 (4): 448-454. PDF icon Read article.

Exception from Informed Consent (EFIC)

Biros MH, Dickert NW, Wright DW, Scicluna VM, Harney D, Silbergleit R, Denninghoff K, Pentz RD. Balancing Ethical Goals in Challenging Individual Participant Scenarios Occurring in a Trial Conducted with Exception from Informed Consent. Acad Emerg Med. 2015 Feb 25. doi: 10.1111/acem.12602. [Epub ahead of print] Learn more.

Dickert NW, Mah VA, Biros MH, Harney DM, Silbergleit R, Sugarman J, Veledar E, Weinfurt KP, Wright DW, Pentz RD. Consulting Communities When Patients Cannot Consent: A Multicenter Study of Community Consultation for Research in Emergency Settings. Critical Care Medicine. 2013 Oct 18. doi: 10.1097/CCM.0b013e3182a27759.PDF icon Read article.

Biros M. The meaning of opt-out. Resuscitation. 2013; 84 (8): 1019-1020. PDF icon Read article.

Biros MH. Does community consultation matter? Academic Emergency Medicine. 2013; 20 (1): 104-105. PDF icon Read article.

Silbergleit R, Biros MH, Harney D, Dickert N, Baren J on behalf of the NETT Investigators. Implementation of the Exception from Informed Consent Regulations in a Large Multicenter Emergency Clinical Trials Network: The RAMPART Experience. Academic Emergency Medicine. April 2012; 19 (4): 448-454. PDF icon Read article.

Biros M. The People Speak: Community Consultation in Emergency Research. Annals of Emergency Medicine. 2011; 57 (4): 355-356. DOI: 10.1016/j.annemergmed.2010.08.028. PDF icon Read article.

Michelle H. Biros, MD, MS, Corey Sargent, MA NREMT-P, and Kathleen Miller, BSN, RN.  Community Attitudes towards Emergency Research and Exception from Informed Consent. Resuscitation. Dec 2009; 80(12): 1382–1387. Published online Oct 8, 2009. doi:  10.1016/j.resuscitation.2009.08.019. PDF icon Read article.

Baren JM, Biros MH.  The research on community consultation: an annotated bibliography. Acad Emerg Med. 2007 Apr;14(4):346-52. PDF icon Read article.

Biros MH. Research without consent: current status, 2003.  Ann Emerg Med. 2003 Oct;42(4):550-64. PDF icon Read article.